![]() However, acquisition of resistance led to altered metabolites in both cell lines tested. The results unveiled that acute nab-paclitaxel treatment affected primary metabolism to a minor extent. After establishment of nab-paclitaxel resistant cell lines, comparison of parental and resistant PDAC cell lines by metabolomics and biochemical assessments revealed altered metabolism, enhanced viability and reduced apoptosis. Here, we report the impact of nab-paclitaxel on the cellular metabolome of PDAC cell lines. One reason for that high mortality is the limited availability of effective chemotherapy as well as the intrinsic or acquired resistance against it. Pancreatic ductal adenocarcinoma (PDAC) correlates with high mortality and is about to become one of the major reasons for cancer-related mortality in the next decades.
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